Drug-Induced Nutrient Depletions

Drug-Induced Nutrient Depletions

Female hormones                                        These deplete the following:

Estrogen replacement therapy Vitamin B6, magnesium
Oral contraceptives Vitamins B1, B2, B3, B6, B12, C, folic acid, magnesium, selenium, zinc, tyrosine

Blood pressure regulators                          These deplete the following:

Hydralazine Vitamin B6, Coenzyme Q10,
Loop diuretics Calcium, magnesium, potassium, sodium, zinc, vitamins B1, B6, vitamin C
Thiazide diuretics Magnesium, phosphorus, potassium, sodium, zinc, Coenzyme Q10
Potassium-sparing diuretics Folic acid, calcium, zinc
Blood pressure regulators Zinc

Cholesterol-lowering drugs                         These deplete the following:

Hydromymethylglutaryl Coenzyme Q10, coenzyme A reductase inhibitors (statins)
Bile acid sequestrants Vitamins A, D, E, K, B12, beta-carotene, folic acid, calcium, iron, magnesium
Gemfibrozil phosphorus, zinc, fat (“fibrates” deplete vitamin E, Vitamin B12, copper, zinc) Coenzyme Q10, vitamin E

Anticonvulsants                                            These deplete the following:

Phenobarbital and barbiturates Vitamin D and K, biotin, folic acid, calcium
Phenytoin Vitamin D, Vitamin K, folic acid, vitamins B1 and B12, biotin, calcium
Carbamazepine Vitamin D, folic acid, biotin
Primidone Biotin, folic acid, vitamins D and K
Valproic acid Folic acid, carnitine

Anti-inflammatory drugs                          These deplete the following:

Corticosteroids Vitamins A, C, D, B12, folic acid, calcium, chromium, magnesium, potassium selenium, zinc
Gout medications Beta-carotene, vitamin B12, calcium, sodium, potassium, phosphorus
Sulfasalazine Folic acid
Indomethacin Folic acid, iron
Other nonsteroidal antiinflammatory drugs Folic acid

Antibiotics Anti-diabetic drugs               These deplete the following:

Antibiotics (General) Acidophilus and Bifidus, all B vitamins, vitamin K
Tetracycline antibiotics Calcium, magnesium, iron
Tuberculosis drugs Vitamin B3, vitamin B6, vitamin D
Neomycin Beta-carotene, calcium, magnesium, iron, potassium, vitamin A, vitamin B12
Trimethoprim Biotin, folic acid, inositol, B vitamins, vitamin K
Sulfonylureas Coenzyme Q10, vitamin E
Biguanides Coenzyme Q10, vitamin B12, folic acid

Ulcer medications                                   These deplete the following:

H2-receptor antagonists Vitamin B12, folic acid, vitamin D, calcium, iron, zinc (protein)*
Proton pump inhibitors Vitamin B12 (protein)*

Other categories and/or commonly prescribed drugs          These deplete the following:

Digoxin Calcium, magnesium, phosphorus
Beta blockers Coenzyme Q10, melatonin
Tricyclic antidepressants Coenzyme Q10, vitamin B2
Phenothiazines Coenzyme Q10, vitamin B2, melatonin
Potassium chloride supplementation Vitamin B12
Chemotherapeutic drugs Most nutrients
Theophylline Vitamin B6
Anticoagulants Vitamin K
Reverse transcriptase inhibitors Copper, zinc, vitamin B12, carnitine

Over-the-counter drugs                         These deplete the following:

Aspirin Vitamin C, folic acid, iron, potassium
NSAIDs Folic acid
Laxatives-mineral oil Vitamins A, D, E, K, beta carotene
Laxatives-bisacodyl Potassium
Magnesium and aluminum antacids Calcium, phosphate, folic acid, (protein)*
Sodium bicarbonate Folic acid, magnesium, potassium, (protein)*
Ulcer medications Vitamin B12, folic acid, vitamin D, zinc

*Problems with the digestion of proteins with use of these drugs have not been documented by scientific studies. However, it is well known that stomach acid is required for proper protein digestion. Therefore, drugs that either neutralize stomach acid or suppress the production of stomach acid are likely to have a negative effect on protein digestion. The passing of undigested protein from the stomach into the small intestine may also cause health problems in its own right.

— From Drug Nutrient Depletions, Ross Pelton, R.Ph., Ph.D. and James B. LaValle, R.Ph.